- Elevated levels of thyroid-stimulating hormone (TSH) are associated with hyperandrogenism (HA) in women with euthyroid polycystic ovary syndrome (PCOS).
Why this matters
- The effects of TSH variation are poorly understood in this patient population.
- Women with PCOS and elevated TSH levels (>2.5 and ≤5.0 mIU/L) had higher risk for HA compared with women with lower TSH levels (≥0.25 and ≤2.5 mIU/L) in multivariate analysis (OR, 1.143; P=.038).
- TSH levels were positively correlated with triglyceride (TG; P=.003), apoβ (P=.037), free testosterone (P=.007), and free androgen index (P<.001 and negatively associated with apoa>
- TG was also associated with HA in women with PCOS in multivariate logistic regression analysis (OR, 1.343; P=.043).
- 600 women with PCOS and 200 matched control participants were included.
- Funding: Major Chronic Non-communicable Disease Prevention and Control Research; National Key R&D Program of China; National Natural Science Foundation of China; Chinese Medical Association; Squibb Endocrinology Diabetes Research; Natural Science Foundation of Shanghai.
- Cross-sectional study design.