Euthyroid PCOS: high TSH tied to hyperandrogenism

  • Cai J & al.
  • Front Endocrinol (Lausanne)
  • 1 Jan 2019

  • International Clinical Digest
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Takeaway

  • Elevated levels of thyroid-stimulating hormone (TSH) are associated with hyperandrogenism (HA) in women with euthyroid polycystic ovary syndrome (PCOS).

Why this matters

  • The effects of TSH variation are poorly understood in this patient population.

Key results

  • Women with PCOS and elevated TSH levels (>2.5 and ≤5.0 mIU/L) had higher risk for HA compared with women with lower TSH levels (≥0.25 and ≤2.5 mIU/L) in multivariate analysis (OR, 1.143; P=.038).
  • TSH levels were positively correlated with triglyceride (TG; P=.003), apoβ (P=.037), free testosterone (P=.007), and free androgen index (P<.001 and negatively associated with apoa>
  • TG was also associated with HA in women with PCOS in multivariate logistic regression analysis (OR, 1.343; P=.043).

Study design

  • 600 women with PCOS and 200 matched control participants were included.
  • Funding: Major Chronic Non-communicable Disease Prevention and Control Research; National Key R&D Program of China; National Natural Science Foundation of China; Chinese Medical Association; Squibb Endocrinology Diabetes Research; Natural Science Foundation of Shanghai.

Limitations

  • Cross-sectional study design.