- Exercise is an effective treatment option for late-life depression, according to a meta-analysis of 41 randomized controlled trials.
- 41 randomized clinical trials met inclusion criteria.
- Exercise interventions included aerobic and non-aerobic exercise.
- Exercise was associated with a 43% reduction in depression severity (SMD = 0.57, 95% CI 0.36 to 0.78).
- This finding did not vary according to different ages of participants, types of control groups, or types of exercise interventions.
- Studies that required a diagnosis of depression had significantly greater mean effect sizes than studies that only required depression symptoms.
- This was a meta-analysis using a random effects model to characterize the benefit of exercise for late-life depression.