Facial psoriasis linked to reduced QoL, but ixekizumab helps

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  • Facial psoriasis is associated with reduced health-related QoL (HRQoL), while ixekizumab (IXE) treatment is associated with facial clearance.

Why this matters

  • Combined results of UNCOVER-2 and UNCOVER-3 trials suggest the efficacy of ixekizumab for facial psoriasis, which is linked to QoL.

Key results

  • Clearance of facial psoriasis was associated with improved Dermatology Life Quality Index 0-1 response (P<.01 for IXE every 4 wk) and Psoriasis Skin Appearance Bothersomeness score (P<.01 for IXE every 2 wk) compared with not achieving facial clearance.
  • IXE treatment was associated with increased facial clearance (84.1% for every 2 wk, 78.7% for every 4 wk) compared with etanercept (67.9%; P<.001 vs IXE every 2 wk and P<.01 vs IXE every 4 wk) and placebo (24.6%; P<.001 vs IXE every 2 wk and IXE every 4 wk).

Study design

  • 2570 patients with moderate-to-severe psoriasis, 1133 with facial psoriasis and 1437 without, were randomly assigned to placebo, etanercept twice-weekly, or ixekizumab every 4 wk or every 2 wk and analyzed for outcomes at 12 wk.
  • Combined results of 2 phase 3 multicenter, randomized, double-blind, placebo-controlled, active-comparator trials.
  • Funding: Eli Lilly and Company.


  • No measure of site or severity of facial psoriasis.