- A family history of mental and/or neurological disorders was associated with a significant increased risk for autism spectrum disorder (ASD) with and without intellectual disability (ID).
- The closer the relative with the family history of mental and/or neurological disorders, the higher the ASD risk.
Why this matters
- The association was stronger for ASD without ID, suggesting ASD without ID may be more familial than ASD with ID.
- 567,436 index persons who were nonadopted singleton births born between 1984 and 2009 and at least 2 years of age at the end of follow-up were included.
- Funding: None disclosed.
- Having ASD without (OR, 9.0; P<.0001 or with p id affected vs unaffected first-degree relatives increased odds of asd without in index persons.>
- Having first-degree relative with cerebral palsy (P<.01 epilepsy or migraine increased odds of asd without id in index persons.>
- A first-degree relative with ASD with (OR, 14.2; P<.0001 or without p id increased odds of asd with in index persons.>
- A first-degree relative with cerebral palsy (P<.01 or epilepsy doubled odds of asd with id in index persons.>
- Data on multiple births not included.
Coauthored with Antara Ghosh, PhD