Family history of mental/neurological disorders tied to ASD risk

  • Xie S & al.
  • JAMA Netw Open
  • 1 Mar 2019

  • International Clinical Digest
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Takeaway

  • A family history of mental and/or neurological disorders was associated with a significant increased risk for autism spectrum disorder (ASD) with and without intellectual disability (ID).
  • The closer the relative with the family history of mental and/or neurological disorders, the higher the ASD risk.

Why this matters

  • The association was stronger for ASD without ID, suggesting ASD without ID may be more familial than ASD with ID.

Study design

  • 567,436 index persons who were nonadopted singleton births born between 1984 and 2009 and at least 2 years of age at the end of follow-up were included.
  • Funding: None disclosed.

Key results

  • Having ASD without (OR, 9.0; P<.0001 or with p id affected vs unaffected first-degree relatives increased odds of asd without in index persons.>
  • Having first-degree relative with cerebral palsy (P<.01 epilepsy or migraine increased odds of asd without id in index persons.>
  • A first-degree relative with ASD with (OR, 14.2; P<.0001 or without p id increased odds of asd with in index persons.>
  • A first-degree relative with cerebral palsy (P<.01 or epilepsy doubled odds of asd with id in index persons.>

Limitations

  • Data on multiple births not included.

Coauthored with Antara Ghosh, PhD

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