- Fatty liver was associated with greater severity of acute pancreatitis in a meta-analysis.
Why this matters
- Prior studies have made the association between fatty liver and pancreatitis incidence, but not severity.
- Meta-analysis of 4 studies involving patients with acute pancreatitis in presence (n=805) or absence (n=1026) of fatty liver.
- Funding: National Nature Science Foundation of China.
- Fatty liver was associated with increased incidence of:
- Persistent organ failure (>48 hours; OR=2.32; P=.002; I2=26.4%).
- Systemic complications (OR=3.60; P<.001 i>2=0%).
- Systemic inflammatory response syndrome (OR=2.82; P<.001 i>2=0%).
- Metabolic disturbance (OR=3.90; P<.001 i>2=0%).
- Mortality (OR=4.16; P<.001 i>2=0%).
- Local complications (all P<.001 including acute necrotic collection>2=51.7%), peripancreatic fluid collection (OR=4.10; I2=0%), and pancreatic pseudocyst (OR=2.79; I2=0%).
- Using revised Atlanta classification, fatty liver was associated with increased incidence of:
- Moderately severe pancreatitis (OR=2.72; P<.001 i>2=70.8%).
- Severe pancreatitis (OR=3.57; P<.001 i>2=73.9%).
- Fatty liver was tied to worse prognosis of acute pancreatitis in stratified analyses by presence of obesity and alcohol abuse.
- Studies were from Korea, China, and Croatia.
- Few studies; relatively small sample size.
- Heterogeneity (I2 statistic).