- Asymptomatic colonic diverticulosis is more likely in patients with moderate or severe fatty liver.
- Waist-hip ratio is also a factor.
Why this matters
- Knowing the risk factors for asymptomatic diverticulosis could help prevent complications, such as diverticular bleeding and diverticulitis, that affect up to 30% of the patients with the disease.
- Researchers analysed the health records of patients screened for diverticulosis during colonoscopy (N=937), comparing them by screening results for associations such as age, sex, alcohol use, smoking status, lipid profile, BMI, visceral fat area, waist-hip ratio, and fatty liver.
- Funding: None.
- Overall diverticulosis prevalence was 8.1% (76/937).
- Mean waist-hip ratio was 0.92±0.05 in patients with diverticulosis vs 0.90±0.05 in those without (P=.052).
- Fatty liver was found in 69.7% (53/76) of the patients with diverticulosis vs 50.3% (433/861) of those without (P=.001).
- Multivariate analysis showed that both the factors were associated with increased asymptomatic diverticulosis risk:
- Waist-hip ratio: OR, 1.035; P=.043.
- Moderate fatty liver: OR, 2.238; P=.043.
- Severe fatty liver: OR, 5.519; P=.025.
- The study was retrospective and single centre, with a small number of patients who were screened positive.
- Researchers did not control for age or adjust for potential confounding factors such as diet, exercise, and medication.