- Folic acid supplementation is associated with lower risk for neural tube defects (NTDs) and miscarriage.
Why this matters
- NTDs have been associated with low folic acid and first-trimester fever.
- These authors conclude that spontaneous abortion may result from severe NTDs and that maternal folic acid supplementation may reduce NTD risk associated with spontaneous abortion.
- The risk for NTDs was increased with a history of (aORs; 95% CIs):
- Spontaneous abortion: 2.59 (1.07-6.27);
- Maternal first-trimester fever: 2.88 (1.16-7.14); and
- No folic acid supplementation: 8.26 (3.09-22.06).
- Interactions between no folic acid and a history of spontaneous abortion (aOR, 18.68; 95% CI, 4.43-78.76) further increased risks for NTD.
- Other interactions were not statistically significant.
- Population-based case-control study.
- Cohorts obtained from the primary health care surveillance system and population-based birth defect surveillance system in China.
- Families with NTD history (n=104) compared with families without NTD history (n=100) between 1993 and 2002.
- Funding: National Natural Science Foundation of China and Danone Nutrition Center for Dietary Nutrition Research and Education Foundation.
- Data on dietary folate intake, dose of folic acid supplementation, and maternal plasma folate concentration not collected.