- No difference in the rates of clinical pregnancy or live birth rate in infertile women without PCOS using fresh and frozen embryos during in vitro fertilization (IVF).
Why this matters
- Previously frozen embryos have been associated with fewer complications and better neonatal outcomes compared with fresh embryos.
- 36.3% had ongoing pregnancy in the frozen-embryo group compared with 34.5% in the fresh-embryo group (P=.65).
- Rates of implantation, clinical pregnancy, and live birth did not differ between groups.
- Fewer small for gestational age babies (<10th percentile) were born in the frozen-embryo group compared with the fresh-embryo group (P=.01).
- Single-center, randomized, control trial.
- Women with infertility who were scheduled for IVF and did not have PCOS were included.
- Frozen-embryo transfer (n=391) was compared with fresh-embryo transfer (n=391).
- Primary outcome was ongoing pregnancy after the first transfer of embryos.
- Funding: My Duc Hospital, Ho Chi Minh City, Vietnam.
- Limited to a single center in Vietnam; results may not be generalizable.