Gastric bypass benefits severely obese adolescents

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Takeaway

  • Roux-en-Y gastric bypass surgery results in substantial and durable bodyweight reduction and cardiometabolic benefits for severely obese adolescents.

Why this matters

  • Little is known about the durability of early responses to bariatric surgery for severe adolescent obesity.

Study design

  • Researchers conducted a prospective follow-up analysis of patients aged 13-21 y who underwent Roux-en-Y gastric bypass for clinically severe obesity (N=58).

  • Outcomes assessed 5-12 y after surgery included BMI, comorbidities, micronutrient status, safety, and other risks.

  • Funding: Ethicon Endosurgery, National Center for Advancing Translational Sciences.

Key results

  • At baseline, the mean age of the cohort was 17.1 y and mean BMI was 58.5 kg/m2.

  • At mean follow-up of 8.0 y, the mean age of the cohort was 25.1 y and mean BMI was 41.7 kg/m2 (mean change in BMI, −29.2%).

  • From baseline to long-term follow-up, significant declines were recorded in the prevalence of elevated blood pressure (27/57 [47%] vs 9/55 [16%]; P=.001), dyslipidemia (48/56 [86%] vs 21/55 [38%]; P<.0001), and type 2 diabetes (9/56 [16%] vs 1/55 [2%]; P=.03).

Limitations

  • The study did not include a nonoperative control group.