- Negative Helicobacter pylori status is associated with poorer prognosis in de novo gastric diffuse large B-cell lymphoma (DLBCL).
Why this matters
- Previous studies have suggested an association between positive H pylori status and less aggressive de novo DLBCL.
- Citing “limited” previous data, these authors say that their findings offer an opening in the early disease stages, when H pylori status is easily assessed, to identify patients with differential outcomes.
- Median follow-up was 52.2 (range, 4-116) months.
- OS for entire group was 78.7%.
- Median OS: 96.0 (95% CI, 88.9-103.0) months.
- Median PFS: 91.8 (95% CI, 83.8-99.7) months.
- 5-year survival with positive vs negative H pylori status:
- OS: 89.7% vs 71.8%; P=.033.
- PFS: 89.3% vs 74.1%; P=.040.
- Positive H pylori status was significantly associated with better PFS (P=.045) and OS (P=.021) outcomes.
- Infection status showed associations specifically at stage I or II disease but not at stage IIE or IV.
- Retrospective analysis of data for 129 patients (51.2% women; median age, 55 [range, 21-84] years) diagnosed with primary de novo gastric DLBCL, January 2009-May 2016.
- 49.6% were H pylori negative.
- Funding: None disclosed.
- Monocentric, retrospective design.
- Some differential treatments.