- Lidocaine gel combined with topical fentanyl reduces pain from prostate biopsy more effectively than lidocaine alone, without the adverse effects and cost of a peripheral nerve block.
Why this matters
- Lidocaine gel alone often does not provide adequate analgesia during prostate biopsy.
- This double-blind randomized clinical trial examined patients undergoing prostate biopsy (N=96) randomly assigned to either a treatment group receiving intrarectal lidocaine gel (2%) 50 g or an intervention group receiving lidocaine gel (2%) 50 g and fentanyl gel 50 µg.
- Researchers recorded patient visual analog scale (VAS) scores during the biopsies and monitored BP, heart rate, and patient level of consciousness.
- Funding: None disclosed.
- The mean VAS score was significantly better in the intervention group (3.0±2) than in the treatment group (5.1±2; P<.001>
- Both groups had similar levels of consciousness after biopsy (P=.358).
- Mean BP and heart rate before and during the prostate biopsy were also similar for both groups.
- The study was single-center with a small sample size.