Gestational diabetes mellitus tied to depression risk during pregnancy

  • Miller NE & al.
  • J Psychosom Obstet Gynaecol
  • 7 Jan 2020

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Diagnosis of gestational diabetes mellitus (GDM) was associated with an increased risk for depression during pregnancy.

Why this matters

  • Findings suggest that women with GDM should be regularly screened for depression and referred for counselling because of the harmful effect of depression on the foetal and maternal outcome.

Study design

  • A prospective multi-part survey included 562 pregnant women (46 with GDM and 516 without GDM) based on their clinical obstetrical outcomes.
  • Funding: None disclosed.

Key results

  • Pregnant women with GDM vs those without GDM were at increased risk for depression (15.2% vs 6.2%; P=.021).
  • No significant difference was observed in the history of prior (P=.362) and post-partum (P=.361) depression between pregnant women with GDM vs those without GDM.
  • According to the regression model for the diagnosis of depression, the risk for depression was higher in women with GDM vs those without GDM (adjusted OR [aOR], 2.46; 95% CI, 1.01-6.03; P=.049).
  • Pre-pregnancy body mass index was associated with the diagnosis of depression (aOR, 1.06; 95% CI, 1.01-1.11; P=.015).

Limitations

  • Small sample size.
  • Lack of specific diagnostic criteria for depression.