- Vitamin D and probiotic co-supplementation in women with gestational diabetes mellitus (GDM) has led to significant improvements in metabolic status and pregnancy outcomes.
Why this matters
- Vitamin D and probiotic may reduce the complications related to GDM.
- 87 women with GDM were randomly assigned to receive either vitamin D with probiotic, probiotic only or placebo for 6 weeks.
- Funding: AUMS, Iran.
- Vitamin D and probiotic co-supplementation vs placebo significantly reduced
- fasting plasma glucose (β, −10.99 mg/dL; P<.001 serum insulin levels p=".001)," homeostasis model of assessment-insulin resistance>
- triglycerides (β, −37.56 mg/dL; P<.001 in mothers.>
- very-low-density lipoprotein (VLDL; β, −7.51 mg/dL; P<.001 high-density lipoprotein cholesterol ratio p high sensitivity c-reactive protein mg malondialdehyde in infants.>
- quantitative insulin sensitivity check index (β, 0.01; P=.001) in mothers.
- HDL-cholesterol (β, 4.09 mg/dL; P=.008), total antioxidant capacity levels (β, 97.77 mmol/L; P<.001 in infants.>
- Microbiota characterisation was not done.