Gestational diabetes mellitus: vitamin D and probiotic co-supplementation improves outcomes

  • Jamilian M & al.
  • Clin Nutr
  • 10 Nov 2018

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Vitamin D and probiotic co-supplementation in women with gestational diabetes mellitus (GDM) has led to significant improvements in metabolic status and pregnancy outcomes.

Why this matters

  • Vitamin D and probiotic may reduce the complications related to GDM.

Study design

  • 87 women with GDM were randomly assigned to receive either vitamin D with probiotic, probiotic only or placebo for 6 weeks.
  • Funding: AUMS, Iran.

Key results

  • Vitamin D and probiotic co-supplementation vs placebo significantly reduced
    • fasting plasma glucose (β, −10.99 mg/dL; P<.001 serum insulin levels p=".001)," homeostasis model of assessment-insulin resistance>
    • triglycerides (β, −37.56 mg/dL; P<.001 in mothers.>
    • very-low-density lipoprotein (VLDL; β, −7.51 mg/dL; P<.001 high-density lipoprotein cholesterol ratio p high sensitivity c-reactive protein mg malondialdehyde in infants.>
  • Vitamin D and probiotic co-supplementation vs placebo significantly increased
    • quantitative insulin sensitivity check index (β, 0.01; P=.001) in mothers.
    • HDL-cholesterol (β, 4.09 mg/dL; P=.008), total antioxidant capacity levels (β, 97.77 mmol/L; P<.001 in infants.>
  • Vitamin D and probiotic co-supplementation did not change other metabolic parameters.
  • Compared with probiotic only group, vitamin D and probiotic co-supplementation significantly reduced triglycerides (P=.02), VLDL-cholesterol (P=.02) and hs-CRP (P=.01), and significantly increased total antioxidant capacity levels (P=.006) and total glutathione levels (P=.04).

Limitations

  • Microbiota characterisation was not done.

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