- Cachexia is associated with inferior survival in patients with gastrointestinal (GI) cancers, particularly in those with upper GI cancers.
Why this matters
- Half of all cancer deaths worldwide are attributable to cachexia; GI cancers have the highest incidence of cachexia.
- Study to investigate changes in body weight in 801 patients with GI cancer.
- Patient data were sourced from a single institution.
- 66.5±11.9 (range, 21-95) years mean patient age.
- Patient BMI at initial observation:
- 62.0% were BMI high (≥25 kg/m2).
- 30.1% were BMI normal (20 to 2).
- 7.8% were BMI low (2).
- Funding: None disclosed.
- Significant interaction between primary cancer site and days of observation (F=8.24; P<.001 with patients colorectal cancer with: style="list-style-type:circle;">
- gastric cancer lost 0.033 kg more per day (t=−5.11; P<.001>
- esophageal cancer lost 0.027 kg more per day (t=−4.18; P<.001>
- pancreatic cancer lost 0.018 kg more per day (t=−3.58; P<.001 and>
- hepatobiliary cancer lost 0.008 kg more per day (t=−1.90; P=.029).
- Female sex: F=64.93; P<.001.>
- Baseline cancer stage: F=7.28; P<.001.>
- Retrospective data.