Gout linked to 14% higher risk for Parkinson's disease in elders

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Takeaway

  • Gout in the elderly (≥65 year) is associated with a 14% increased risk for incident Parkinson's disease (PD), according to a large analysis of Medicare claims data.
  • The increased risk is restricted to those aged 65 to

Why this matters

  • Gout should be aggressively treated in patients with PD risk factors.
  • The mechanism behind the association is unknown.
  • A similarly designed study by the same authors found that gout increased risk for dementia.

Study design

  • Retrospective cohort of 22,636 incident PD cases among a 5% random sample of 1.72 million Medicare recipients (2006-2012) based on claims data.
  • Funding: University of Alabama at Birmingham; Birmingham VA Medical Center.

Key results

  • Crude incidence rate of PD was higher in people with gout than in those without gout (3.7 vs 2.2 per 1000 person-years).
  • In multivariate analysis, gout was associated with 14% higher risk for incident PD (HR, 1.14; 95% CI, 1.07-1.21).
  • In subgroup analysis, there were no gender or race differences in risk, but there was an age effect:
    • People with gout aged 65 to

Limitations

  • Reliance on claims data.
  • Retrospective, observational design.