Gout tied to increased risk for venous thromboembolism

  • Sultan AA & al.
  • CMAJ
  • 3 Jun 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Gout was associated with a higher risk for first venous thromboembolism (VTE); although risk increased with age, the excess risk was higher for younger patients (age,
  • The increased risk was independent of hospital admission, and no difference in the risk of VTE was observed by prescription of urate-lowering therapy.

Why this matter

  • Findings suggest that observed excess risk may not be enough to warrant preventive interventions; however, clinical vigilance may be required when taking care of these patients.

Study design

  • Population-based study of 62,234 patients with gout identified from the UK Clinical Practice Research Datalink (CPRD), matched with 62,234 controls.
  • Funding: National Institute for Health Research School for Primary Care Research (NIHR SPCR).

Key results

  • The risk for VTE was higher in patients with gout vs controls (absolute rate, 37.3 vs. 27.0 per 10,000 person-years; aHR, 1.25; 95% CI, 1.15-1.35).
  • Absolute rate of VTE increased with age (Ptrends>.001) and was higher for younger patients (age,
  • VTE risk was higher when the patient was not hospitalised (incidence rate ratio [IRR], 1.30; 95% CI, 1.18-1.42) and not during the in-hospital period (IRR, 1.01; 95% CI, 0.83-1.24).
  • The risk for VTE was similar among patients with or without urate-lowering therapy prescription (IRR, 1.04; 95% CI, 0.89-1.23).

Limitations

  • Use of anonymised patient records.