- A single calculated dose of radioactive iodine (RAI) is associated with a >90% success rate for treating Graves' hyperthyroidism at a single center.
Why this matters
- The goals and methods of RAI therapy for Graves' disease vary widely, with little analysis of using a single dose to eliminate hyperthyroidism.
- 295 (93.4%) of 316 patients were successfully treated (hypothyroidism within 3-6 months) with a single dose.
- 18 patients were successfully treated with a second dose,
- 2 patients were successfully treated with a third dose, and
- 1 patient underwent thyroidectomy.
- Failure of RAI therapy was associated with previous propylthiouracil therapy (P=.004).
- The mean response time after successful RAI ablation was 110.2 days.
- Cumulative response rates of 25% at 61 days, 50% at 84 days, and 75% at 118 days.
- 316 patients with Graves' disease and associated hyperthyroidism, 56.6% with no prior therapy, 1.9% who received thyroid surgery, and 41.5% treated with antithyroid medications, were treated with a calculated RAI dose (0.2 mCi/estimated gram thyroid tissue, adjusted for 24-hour RAI uptake) and analyzed for outcomes.
- Funding: None.
- Retrospective study.
- Adverse effects not reported.