Guidelines for first-episode schizophrenia pharmacological treatment reviewed

Access to the full content of this site is available only to registered healthcare professionals. Register to read more


  • The National Institute for Health and Care Excellence (NICE), Scottish Intercollegiate Guidelines Network (SIGN), and Spanish guidelines fared best, and there is overall agreement that clozapine (Clozaril, FazaClo ODT, Versacloz) is the first choice for treatment-resistance.

Why this matters

  • About 75% of individuals with schizophrenia will experience a relapse after the first episode. The study is the first to look at the quality of guidelines for treatment of first-episode schizophrenia.

Study design

  • The researchers used the Appraisal of Guidelines for Research and Evaluation II instrument to analyze 10 guidelines.
  • Funding: The study received no funding.

Key r...