Routine cardiac testing before, during, or after treatment with pegylated liposomal doxorubicin (PLD) may not be necessary in patients with gynecologic cancer.
Why this matters
The manufacturer recommends evaluations via endomyocardial biopsy, echocardiography, or multigated acquisition scan (MUGA) before and during treatment. Findings suggest testing could be reserved for high-risk patients.
- Researchers analyzed the health records of 235 patients (mean age, 62±11 years, 37% black) receiving PLD for gynecologic cancer.
- A Wilcoxon signed-rank sum test and logistic regression were used to evaluate the association between cumulative PLD exposure with cardiotoxicity.
- Funding: National Institutes of Health.
- Data for 56 patients with both pre- and posttreatment cardiac testing showed no significant difference in median ejection fraction (P=.17).
- 3 patients experienced PLD-associated cardiac toxicity, but only 1 patient had severe symptoms requiring treatment discontinuation.
- Retrospective, observational data.