Hashimoto's disease: thyroidectomy or medical management


  • Mary Corcoran
  • Univadis Medical News
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Findings from a new trial suggest total thyroidectomy is more effective than medical management for Hashimoto's disease. 

The trial included 150 individuals aged between 18 and 79 years attending a secondary care hospital in Norway. All individuals had persistent Hashimoto-related symptoms despite euthyroid status while receiving hormone replacement therapy and with serum antithyroid peroxidase (anti-TPO) antibody titres greater than 1,000 IU/mL. 

Seventy-three patients underwent total thyroidectomy with standard medical therapy, whereas 74 received standard medical therapy only. 

At 18 months follow-up, only patients in the surgical group demonstrated improvement in measures of health-related quality of life and fatigue. Mean general health score increased from 38 to 64 points for a between-group difference of 29 points (95% CI 22-35; P<.001 fatigue score decreased from to points a between-group difference of ci p chronic frequency cent per percentage median serum anti-tpo antibody titres also in the surgical group but not medical therapy group.>

The findings are published in the Annals of Internal Medicine

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit