- Laparoscopic liver resection (LLR) was associated with a higher recurrence-free survival and similar postoperation complication rate to radiofrequency ablation (RFA) in patients with single, small hepatocellular carcinoma (HCC).
Why this matters
- LLR has the efficacy of open liver resection and the safety of RFA, suggesting it should be the first-line therapy in this patient population.
- Propensity score-matched analyses of open LR vs RFA (n=182) and laparoscopic LR vs RFA (n=100).
- Funding: None disclosed.
- Open LR vs RFA:
- No significant between-group difference in 3-year or 5-year OS.
- 3-year recurrence-free survival (RFS): LR, 41% vs RFA, 30% (P
- 5-year RFS: LR, 36% vs RFA, 21% (P<.001>
- Median follow-up, 33 months. Death rate was higher in LR (36.2% vs 21.9%), but recurrence was lower (58% vs 69%).
- After propensity-score matched analysis, cirrhosis was more common in RFA patients (89% vs 84%; P=.04), but less likely to be superficial (56% vs 86%; P<.01>
- 3-year and 5-year OS rates were similar.
- RFS was higher with LLR at 3 years (54% vs 26%; P<.001 and years vs p>
- Perioperative comorbidity, 8% LLR vs 4% RFA (P=.43).
- Retrospective analysis.