- Patients with hepatocellular carcinoma (HCC) who received multidisciplinary care had improved 5-year survival rates, particularly those with poor liver function, intermediate or advanced tumor stage, or high alphafetoprotein (AFP) levels.
- The multidisciplinary team (MDT) met once a week and included hepatologists, surgeons, diagnostic radiologists, interventional radiologists, radiation oncologists, medical oncologists, pathologists, and coordinators. Each team discussed a maximum of 15 cases in 1 hour.
Why this matters
- A multidisciplinary approach is recommended for HCC, but there is limited evidence that it improves outcome.
- Retrospective analysis of 6619 cases and an exactly matched cohort (n=1396).
- Funding: None.
- 738 patients (11.1%) were managed through MDT.
- Patients who received MDT were older, were more likely to be men, had more preserved liver function, and had less advanced tumor stage.
- 5-year OS was higher in MDT: 71.2% vs 49.4% (P<.001>
- In the exactly matched cohort, 5-year OS was higher in the MDT group: 71.7% vs 58.9% (P<.001>
- MDT effect was greater for baseline albumin-bilirubin grade 2 (HR, 0.56) or 3 (HR, 0.16), BCLC stage B (HR, 0.40) or C (HR, 0.38), and serum AFP levels ≥200 ng/mL (HR, 0.50).
- Single center.
- Korean population.