- African-American patients receiving liver transplants for early hepatocellular carcinoma (HCC) had better survival when they received a liver from an African-American donor.
Why this matters
- African-Americans have worse HCC survival than other populations. Most research has focused on recipient characteristics to explain this differential.
- Donor-recipient race mismatch has been linked to worse survival in lung, kidney, and heart transplant patients.
- Analysis of liver transplantation records from the United Network for Organ Sharing Organ Procurement and Transplant Network database from 1994 to 2015 (n=1384 African-American recipients).
- Funding: None disclosed.
- 23.5% of recipients were race-matched.
- Median OS, race-matched vs non-race-matched (135.0 vs 77.9 months; P=.007).
- 5-year OS, race-matched vs non-race-matched (64.2% vs 56.9%; P=.019).
- Race-matched transplantation was associated with improved OS (HR, 0.66; P=.004).
- Caucasian donor race was a negative predictor of survival compared with African-American donor race (HR, 1.53; P=.004).
- Hispanic donor race and Asian donor race were trended toward being a negative predictor of survival, but did not reach statistical significance.
- Retrospective study.