- HCV is associated with an increased risk for parkinsonism that is attenuated by antiviral treatment.
Why this matters
- Findings add to mounting evidence of a link between HCV and Parkinson’s disease.
- Parkinsonism incidence was higher among patients with HCV vs control patients (492 vs 403 per 100,000 person-years; P<.0001>
- HCV was tied to increased risks for (all P<.001 style="list-style-type:circle;">
- Parkinsonism (aHR=1.306);
- Requiring anti-Parkinson medication (aHR=1.323); and
- Parkinson’s disease (aHR=1.203).
- Case-control study of 49,342 HCV-infected patients propensity-matched 1:1 with non-HCV ‘controls’ from the Taiwanese National Health Insurance Research Database (2004-2012).
- HCV subanalysis: 23,647 patients receiving ≥24 weeks of peginterferon-ribavirin were matched 1:1 with untreated patients.
- Funding: Taiwan Ministry of Science and Technology, Liver Disease Prevention & Treatment Research Foundation of Taiwan, other institutions.
- Observational design based on claims data.