HCV incidence is higher among HIV+ MSM

  • Dig Liver Dis
  • 5 Jun 2018

  • curated by Yael Waknine
  • Univadis Clinical Summaries
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Takeaway

  • HCV acquisition is higher among HIV-positive vs HIV-negative men who have sex with men (MSM), according to a study conducted at the Infectious Diseases Clinic of Modena, Italy.

Why this matters

  • HIV+ MSM who practice condomless sex may be at increased risk for sexually-acquired HCV, which is uncommon in the general population.
  • Annual screening, early management, and behavioral interventions are warranted.

Study design

  • Study of 442 HIV+ MSM outpatients negative for HCV and history of injection drug use.
  • 99.5% of patients received antiretroviral therapy and 92% were virologically suppressed.
  • An HIV− MSM population (n=160) served as controls.
  • Funding: None.

Key results

  • Incidence analysis showed that 19 of 421 (4.5%) HIV+ MSM acquired HCV during a median follow-up of 96 (range, 12-372) months (incidence rate, 0.44 per 100 patient-years).
  • HCV prevalence was 9% (40/442); most cases were genotype 1a (55%) or 3 (22%) with aspartate aminotransferase to platelet ratio index score
  • Univariate analysis revealed increased HCV prevalence among HIV+ vs HIV− MSM (9.0% vs 0.6%; P<.001 coupled with younger median age at years vs p>
  • According to the authors, HCV prevalence in the general Italian population is

Limitations

  • Small sample size, short follow-up.

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