- HCV acquisition is higher among HIV-positive vs HIV-negative men who have sex with men (MSM), according to a study conducted at the Infectious Diseases Clinic of Modena, Italy.
Why this matters
- HIV+ MSM who practice condomless sex may be at increased risk for sexually-acquired HCV, which is uncommon in the general population.
- Annual screening, early management, and behavioral interventions are warranted.
- Study of 442 HIV+ MSM outpatients negative for HCV and history of injection drug use.
- 99.5% of patients received antiretroviral therapy and 92% were virologically suppressed.
- An HIV− MSM population (n=160) served as controls.
- Funding: None.
- Incidence analysis showed that 19 of 421 (4.5%) HIV+ MSM acquired HCV during a median follow-up of 96 (range, 12-372) months (incidence rate, 0.44 per 100 patient-years).
- HCV prevalence was 9% (40/442); most cases were genotype 1a (55%) or 3 (22%) with aspartate aminotransferase to platelet ratio index score
- Univariate analysis revealed increased HCV prevalence among HIV+ vs HIV− MSM (9.0% vs 0.6%; P<.001 coupled with younger median age at years vs p>
- According to the authors, HCV prevalence in the general Italian population is
- Small sample size, short follow-up.