HCV tied to 10-year CVD risk in NHANES, CHMS

  • Badawi A & al.
  • PLoS One
  • 1 Jan 2018

  • curated by Yael Waknine
  • Clinical Essentials
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Takeaway

  • HCV infection is associated with a small but significant 2.5%-3.5% increase in absolute risk for cardiovascular disease (CVD) over a 10-year span.

Why this matters

  • The role of HCV in CVD is controversial; some studies have reported increased risk, others none.
  • Potential mechanisms include metabolic dysregulation as well as chronic inflammation and/or endothelial dysfunction.

Study design

  • Analysis of participants aged 30-74 years with no CVD history in the US National Health and Nutrition Survey (NHANES 2007-2016; n=16,668) and Canadian Health Measures Survey (CHMS 2007-2015, n=10,115).
  • HCV prevalence: NHANES, 1.95%; CHMS, 0.9%.
  • Funding: Public Health Agency of Canada.

Key results

  • HCV+ individuals had a distinct sociodemographic profile, but similar cardiometabolic risk factors, inflammatory markers, and micronutrient serum levels vs HCV-negative counterparts.
  • NHANES showed higher mean Framingham Risk Score (FRS) values in HCV+ vs HCV-negative persons (15.3%±10.4% vs 12.1%±9.8%; P=.047).
  • Mean 10-year FRS-estimated CVD risk was higher (“intermediate”) among HCV+ vs “low” among HCV-negative persons in:
    • NHANES: 14.7±10.3 vs 10.0±10.0 (P<.001>
    • CHMS: 10.5±8.8 vs 8.0±6.6 (P=.008).
  • Multivariate analysis tied HCV to an increase in absolute 10-year CVD risk after adjusting for ethnicity, metabolic syndrome components, and BMI.
    • NHANES: 3.5% (P<.001>
    • CHMS: 2.5% (P<.003>

Limitations

  • HIV status, drug use not captured.

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