HDL from patients with AS displays impaired antiatherogenic properties

Access to the full content of this site is available only to registered healthcare professionals. Register to read more

Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with increased risk of cardiovascular disease (CVD). A recent study found that HDL from patients with AS displays impaired antiatherogenic properties. Attenuation of such HDL properties may constitute a link between AS and CVD.


  • HDL (apoB-depleted serum) was isolated from 35 patients with AS and 35 age- and sex-matched controls
  • Measurements: antioxidant capacity of HDL, ability of HDL to induce cholesterol efflux, activity of HDL-associated enzymes paraoxonase-1 (PON1) and myeloperoxidase (MPO), the ability of HDL to induce Akt kinase activation


  • HDL from patients with AS had decreased antioxidant capacity and decreased ability to promote cholesterol efflux from macrophages vs controls
  • HDL-associated PON1 activity was lower and HDL-associated MPO activity higher in patients with AS vs controls
  • Higher MPO activity correlated positively with lower antioxidant capacity of HDL in patients with AS
  • HDL from patients with AS had impaired endothelial Akt kinase activating properties that were inversely correlated with MPO/PON1 ratio and positively correlated with cholesterol efflux capacity of HDL