HDL from patients with AS displays impaired antiatherogenic properties

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Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with increased risk of cardiovascular disease (CVD). A recent study found that HDL from patients with AS displays impaired antiatherogenic properties. Attenuation of such HDL properties may constitute a link between AS and CVD.

Method

  • HDL (apoB-depleted serum) was isolated from 35 patients with AS and 35 age- and sex-matched controls
  • Measurements: antioxidant capacity of HDL, ability of HDL to induce cholesterol efflux, activity of HDL-associated enzymes paraoxonase-1 (PON1) and myeloperoxidase (MPO), the ability of HDL to induce Akt kinase activation

Results

  • HDL from patients with AS had decreased antioxidant capacity and decreased ability to promote cholesterol efflux from macrophages vs controls
  • HDL-associated PON1 activity was lower and HDL-associated MPO activity higher in patients with AS vs controls
  • Higher MPO activity correlated positively with lower antioxidant capacity of HDL in patients with AS
  • HDL from patients with AS had impaired endothelial Akt kinase activating properties that were inversely correlated with MPO/PON1 ratio and positively correlated with cholesterol efflux capacity of HDL