Head/neck BCC: margins predict postsurgical recurrence

  • Gill AS & al.
  • Laryngoscope
  • 5 Mar 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A retrospective study finds 64.5% recurrence-free survival (RFS) following primary surgery for locally aggressive head and neck basal cell carcinoma (BCC), with intraoperative positive frozen section margin, a strong predictor of local recurrence.

Why this matters

  • Locally aggressive BCC of the head and neck is rare and poorly studied.

Key results

  • 5-year estimated RFS was 64.5%, OS was 83.3%, and disease-specific survival was 98.3%.
  • Intraoperative positive frozen section margin (28.6% of tumors) was independently predictive of local recurrence (HR, 6.88; P=.038).
  • Tumors previously treated with radiation (14.3%) were more likely to have intraoperative positive frozen section margins (OR, 6.47; P=.05).

Study design

  • 87 patients with BCC of the head and neck (98 total tumors) were treated with primary surgical resection and analyzed for outcomes and associated outcomes.
  • Funding: None.

Limitations

  • Retrospective study design.
  • Small patient sample size.