- Prophylactic antibiotics are associated with reduced hospitalization risk and lower treatment cost in patients with locally advanced head and neck cancer (HNC) treated with chemoradiotherapy (CRT).
Why this matters
- CRT is associated with high rates of acute toxicity, including pneumonia.
- Patients who received prophylaxis and those who received standard care had similar rates of pneumonia (46.8% vs 45.8%; P=.54).
- Prophylaxis was associated with lower rates of hospitalization (19.1% vs 39.6%; P=.03) and fever (10.9% vs 29.2%; P=.028) compared with standard care.
- Prophylaxis was associated with an average reduction of €1425 per patient (P=.046) compared with standard care.
- 95 patients with CRT-treated HNC, 48 in the standard care group and 47 in the prophylaxis group (amoxicillin/clavulanic acid), were included.
- Funding: Netherlands Organisation for Health Research and Development.
- Relatively low patient number.