- Most invasive breast cancers are associated with having many low-penetrance single nucleotide polymorphisms (SNPs).
- This UK Biobank study finds that a high score for these SNPs is linked to more than doubled likelihood of invasive breast cancer.
- Risk is reduced by up to 31% among women with a highly healthy lifestyle, especially postmenopausal women.
Why this matters
- Findings may empower women with high SNP-related risk to adopt a healthy lifestyle.
- Prospective cohort of 146,326 women; median follow-up, 7.1 years.
- Healthy lifestyle index (HLI) was derived at intake from diet, physical activity, smoking, alcohol intake, and anthropometry data and stratified by tertiles (high, medium, low).
- A polygenic risk score (PRS) was derived from 304 breast cancer associated-genetic loci (SNPs) and stratified by tertiles.
- Funding: Breast Cancer Research Foundation.
- A high (vs low) PRS was associated with a more than doubled risk for invasive breast cancer:
- HR, 2.64 for premenopausal women.
- HR, 2.5 for postmenopausal women.
- Compared with the lowest tertile, the highest tertile of HLI was linked to:
- 22% reduction in breast cancer for premenopausal women (HR, 0.78; 95% CI, 0.64-0.94).
- 31% for postmenopausal women (HR, 0.69; 95% CI, 0.63-0.77).
- Lifestyle was self-reported.