Takeaway
- In patients with heart failure (HF), influenza vaccination was associated with a significant reduction in the risk for all-cause mortality.
Why this matters
- Influenza vaccination is underused in patients with HF.
- Findings suggest that influenza vaccination may have a prognostic impact and influence outcomes in patients with HF.
Study design
- Meta-analysis of 6 studies (n=179,158) evaluating the effects of influenza vaccination vs placebo in patients with HF after a search across electronic database.
- Funding: None.
Key results
- Influenza vaccination was associated with a significant reduction in the risk for all-cause mortality (HR, 0.83; 95% CI, 0.76-0.91; I2=75%; P<.0001).
- The pooled results of 1 trial showed that influenza vaccination vs placebo group had lower risk for HF hospitalisations (HR, 0.69; 95% CI, 0.55-0.86) and recurrent HF hospitalisations (HR, 0.303; 95% CI, 0.178-0.514).
- Risk for CV mortality (HR, 0.92; 95% CI, 0.73-1.15; I2=94%) and all-cause hospitalisations (HR, 1.01; 95% CI, 0.92-1.11; I2=65%) did not significantly differ in vaccination vs placebo group.
Limitations
- Heterogeneity among studies.
- Type and the dose of influenza vaccine were not included.
References
References