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Clinical Summary

Heart failure: influenza vaccination linked to lower all-cause mortality risk

Takeaway

  • In patients with heart failure (HF), influenza vaccination was associated with a significant reduction in the risk for all-cause mortality.

Why this matters

  • Influenza vaccination is underused in patients with HF.
  • Findings suggest that influenza vaccination may have a prognostic impact and influence outcomes in patients with HF.

Study design

  • Meta-analysis of 6 studies (n=179,158) evaluating the effects of influenza vaccination vs placebo in patients with HF after a search across electronic database.
  • Funding: None.

Key results

  • Influenza vaccination was associated with a significant reduction in the risk for all-cause mortality (HR, 0.83; 95% CI, 0.76-0.91; I2=75%; P<.0001).
  • The pooled results of 1 trial showed that influenza vaccination vs placebo group had lower risk for HF hospitalisations (HR, 0.69; 95% CI, 0.55-0.86) and recurrent HF hospitalisations (HR, 0.303; 95% CI, 0.178-0.514).
  • Risk for CV mortality (HR, 0.92; 95% CI, 0.73-1.15; I2=94%) and all-cause hospitalisations (HR, 1.01; 95% CI, 0.92-1.11; I2=65%) did not significantly differ in vaccination vs placebo group. 

Limitations

  • Heterogeneity among studies.
  • Type and the dose of influenza vaccine were not included.

References


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