Takeaway
- Patients with type 2 diabetes (T2D) who developed intercurrent ischaemic heart disease (IHD), end-stage renal disease (ESRD) or both, had a significantly higher risk of developing heart failure (HF) compared to those who did not develop IHD and ESRD.
Why this matters
- Findings suggest that prevention of IHD and ESRD may be an effective way to delay or prevent HF development in patients with T2D.
Study design
- This Danish nationwide cohort study included 285,024 patients (mean age 59 years) with new-onset T2D without previous history of HF between 1998 and 2015.
- Funding: None disclosed.
Key results
- During a median follow-up of 7.4 years, 19,960 (7%) patients developed incident HF.
- The 5-year absolute risk of HF was lowest in patients with T2D without IHD or ESRD (4.02%; 95% CI, 3.90-4.15).
- Patients with T2D complicated by IHD (11.51%; relative risk [RR], 2.86; 95% CI, 2.72-3.02) or ESRD (8.11%; RR, 2.02; 95% CI, 1.39-2.93; P<.001 for both) had an intermediate risk of HF.
- Patients with T2D complicated by both IHD and ESRD had the highest risk (19.76%; RR, 4.92; 95% CI, 3.43-7.05; P<.001).
- Patients with ESRD (RR, 1.47; 95% CI, 1.20-1.79) and with both IHD and ESRD (RR, 1.68; 95% CI, 1.41-1.99; P<.001 for both) were at an increased risk of mortality after HF diagnosis vs those with T2D without IHD and ESRD.
Limitations
- Study did not consider other baseline risk factors, such as concomitant conditions and medical therapy
This clinical summary first appeared on Univadis from Medscape.