- Use of acid-suppressive medications during pregnancy was associated with 36% increase in risk for asthma in offsprings.
- This risk was higher with H2-receptor antagonists (H2RA) use vs proton pump inhibitors (PPI).
Why this matters
- Dyspepsia and gastroesophageal reflux disease are common in pregnant women.
- Previous studies on the use of acid-suppressive medications during pregnancy and risk for asthma in offsprings have shown inconsistent results.
- This meta-analysis included analytical epidemiological studies in women during preconception and pregnancy and their offspring who were aged ≤17 y.
- Funding: None.
- 8 studies with 1,620,043 participants were included.
- The use of acid-suppressive medications was associated with significant risk for asthma (risk ratio, 1.36; I2, 87.6%).
- H2RA (HR, 1.46; I2, 15.3%) showed higher risk for asthma vs PPI (HR, 1.30; I2, 45.2%).
- No conclusion could be made on association of use during any specific trimester and development of asthma.
- Unmeasured confounding factors could have inﬂuenced observation.
- Risk for publication bias.