- A high proportion of hospitalized patients with hematologic malignancies are at risk for malnutrition, which is associated with an increased 1-year mortality risk.
Why this matters
- This is the first study to investigate the relationship between mortality and malnutrition in this setting.
- Study to investigate an association between malnutrition and mortality in 120 hospitalized patients with hematologic malignancies.
- 34.2% of patients had lymphoma, 34.2% had leukemia, 31.7% had multiple myeloma.
- Mean patient age, 53.6 (standard deviation [SD], 14.1) years.
- Funding: None disclosed.
- 81.7% of patients were at risk for malnutrition per Nutrition Risk Screening 2002 (NRS2002); 25.8% were malnourished per Global Leadership Initiative on Malnutrition (GLIM) criteria.
- Proportion of patients with malnutrition by malignancy:
- Lymphoma: 31.7%.
- Leukemia: 29.2%.
- Multiple myeloma: 15.7%.
- The 1-year mortality rate was 41.7%.
- The following were associated with higher mortality risk independent of age and duration since diagnosis:
- Malnutrition: HR, 3.55; 95% CI, 1.99-6.34; P=.001.
- Weight loss risk: HR, 2.82; 95% CI, 1.5-5.3; P=.001.
- Other factors significantly associated with increased mortality risk:
- High C-reactive protein: HR, 2.39; 95% CI, 1.36-4.20; P=.002.
- Low hand grip: HR, 0.51; 95% CI, 0.26-0.99; P=.03.
- Limited sample size.