Hematological malignancies: malnutrition a significant threat to survival

  • Yilmaz M & al.
  • Support Care Cancer
  • 4 Jul 2019

  • curated by David Reilly
  • Univadis Clinical Summaries
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Takeaway

  • A high proportion of hospitalized patients with hematologic malignancies are at risk for malnutrition, which is associated with an increased 1-year mortality risk.

Why this matters

  • This is the first study to investigate the relationship between mortality and malnutrition in this setting.

Study design

  • Study to investigate an association between malnutrition and mortality in 120 hospitalized patients with hematologic malignancies. 
  • 34.2% of patients had lymphoma, 34.2% had leukemia, 31.7% had multiple myeloma.
  • Mean patient age, 53.6 (standard deviation [SD], 14.1) years.
  • Funding: None disclosed.

Key results

  • 81.7% of patients were at risk for malnutrition per Nutrition Risk Screening 2002 (NRS2002); 25.8% were malnourished per Global Leadership Initiative on Malnutrition (GLIM) criteria.
  • Proportion of patients with malnutrition by malignancy:
    • Lymphoma: 31.7%.
    • Leukemia: 29.2%.
    • Multiple myeloma: 15.7%.
  • The 1-year mortality rate was 41.7%.
  • The following were associated with higher mortality risk independent of age and duration since diagnosis:
    • Malnutrition: HR, 3.55; 95% CI, 1.99-6.34; P=.001.
    • Weight loss risk: HR, 2.82; 95% CI, 1.5-5.3; P=.001.
  • Other factors significantly associated with increased mortality risk:
    • High C-reactive protein: HR, 2.39; 95% CI, 1.36-4.20; P=.002.
    • Low hand grip: HR, 0.51; 95% CI, 0.26-0.99; P=.03.

Limitations

  • Limited sample size.

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