- Hypofractionated (HF) vs conventional fractionated (CF) radiotherapy for whole-breast irradation (WBI) in early breast cancer was associated with less frequent and less severe acute radiation-induced skin toxicity (i.e., radiation dermatitis) in this German randomized controlled trial (RCT).
Why this matters
- Results add to evidence of benefits of HF, including shorter duration (2-4 weeks instead of 5-6 weeks), greater convenience, decreased resource use.
- Patients (N=140) were randomly assigned to HF (40.05 Gy in 15 fractions) vs CF (50 Gy in 25 fractions) as adjuvant therapy for WBI.
- Severity and frequency of radiation dermatitis was assessed by 3 methods, including objective photospectrometric skin readings.
- Funding: None disclosed.
- HF vs CF WBI was linked to less severe physician-assessed radiation dermatitis:
- Mean, 1.05 vs 1.43 (P=.024).
- HF WBI was associated with more grade 0 radiation dermatitis (no dermatitis):
- 21.43% vs 4.28%.
- HF also was associated with less grade ≥2 radiation dermatitis:
- 27.14% vs 42.86%.
- By objective photospectrometric measurements (n=4200), HF vs CF was linked to decreased erythema severity (P=.008) and less hyperpigmentation (P=.002).
- Patients assigned to HF WBI also reported less pain (P=.006), less hyperpigmentation (P<.001 and fewer limitations on day-to-day activities>
- Patients were aware of treatment.