Takeaway
- Hidradenitis suppurativa (HS) is associated with risk for cutaneous and extracutaneous infection in children and adults, leading to increased healthcare costs and mortality risk.
Why this matters
- Little was known about the risk for infection in patients with HS.
Key results
- Patients with HS had a higher prevalence of serious infections (33.9% vs 21.6%; aOR, 2.30; P<.0001) compared with patients without HS.
- Increased prevalence was found in both adults (33.95% vs 23.39%) and children (31.78% vs 12.63%) with HS.
- HS was associated with higher odds of herpes simplex virus, herpes zoster, any skin infection, necrotizing fasciitis, pharyngitis, bone infection, Clostridium difficile infection, methicillin-sensitive and methicillin-resistant Staphylococcus aureus, Streptococcus, Pseudomonas, mycobacterial, any fungal infection, any viral infection, septicemia, HIV, hepatitis B, and antibiotic-resistant infections and lower odds of bronchitis, pneumonia, appendicitis, diverticulitis, pyelonephritis, Streptococcus pneumonia, and influenza infections.
- HS inpatients with serious infection had increased inpatient mortality (0.71% vs 0.16%; P<.0001), mean length of stay (7.3 vs 4.8 days, no statistics shown), and cost of care ($13,578 vs $9242, no statistics shown) compared with patients with HS without serious infection.
Study design
- 87,053,155 inpatients, 24,666 with HS, were included.
- Funding: Agency for Healthcare Research and Quality, Dermatology Foundation.
Limitations
- Cross-sectional study.
References
References
