Hidradenitis suppurativa is linked to increased mental health risk: meta-analysis

  • Jalenques I & al.
  • J Am Acad Dermatol
  • 25 Mar 2020

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Hidradenitis suppurativa (HS) is associated with increased risk for anxiety and depression, according to a systematic review and meta-analysis.

Why this matters

  • Prior studies have shown conflicting evidence on the relationship between HS and psychiatric conditions, prompting this meta-analysis.

Key results

  • In the overall meta-analysis, depression prevalence was 21% and anxiety prevalence 12% in patients with HS.
  • Depression and HS were significantly associated in an analysis of 10 case-control studies:
    • OR, 2.01 (95% CI, 1.67-2.48).
      • OR, 1.99 (95% CI, 1.63-2.43) after exclusion of 1 study because of funnel plot publication bias.
  • Anxiety and HS were significantly associated in an analysis of 7 case-control studies:
    • OR, 1.97 (95% CI, 1.65-2.35).

Study design

  • 28 studies of depression in HS and 12 studies of anxiety in HS were included.
  • Funding: None.

Limitations

  • Heterogeneity among included studies.