- Adolescent obesity or overweight in men and women and high-normal BMI in men are linked to increased pancreatic cancer risk.
Why this matters
- Adult obesity is tied to risk for pancreatic cancer, the sixth most common cause of cancer mortality worldwide.
- Accompanying editorial suggests that systemwide inflammation associated with obesity might underlie the connection.
- Median follow-up, 23.3 years.
- In men, BMI values tracked with pancreatic cancer risk, vs low-normal BMI (HRs; 95% CIs):
- High-normal: 1.49 (1.04-2.13).
- Overweight: 1.97 (1.39-2.80).
- Obesity: 3.67 (2.52-5.34).
- For women, vs low-normal BMI, obesity was linked to increased pancreatic cancer risk: HR, 4.07 (95% CI, 1.78-9.29).
- At the population level, obesity/overweight contributed 10.9% (95% CI, 6.1%-15.6%) of risk.
- 1,087,358 Israeli Jewish men and 707,212 women had physical exams at ages 16-19 years (1967-2002).
- BMI categories:
- low-normal (≥5th to th percentile),
- normal weight (5th to th percentile),
- high-normal (≥75th to th percentile),
- overweight (85th to th percentile),
- obesity (≥95th percentile).
- Pancreatic cancer incidence identified through national cancer registry, HRs estimated.
- Funding: Israel Cancer Research Fund (USA); Environment and Health Fund (Israel).
- No data on weight change over time, smoking status, waist-hip ratio.
- No information on BRCA, tied to increased pancreatic cancer risk.