- High levels of low-density lipoprotein (LDL) cholesterol and total cholesterol are linked to reduced risk for Parkinson’s disease (PD) in men.
Why this matters
- The authors say that a role for cholesterol in neurodegeneration is unclear.
- Other studies examining this potential link have included confounders, and the direction of the association is not clear.
- Pooled HRs (95% CI) for PD risk in men vs lowest total cholesterol tertile were as follows:
- 0.82 (0.66‐1.01) for middle tertile, and
- 0.71 (0.55‐0.93) for highest.
- Pooled HRs (95% CI) for PD risk vs lowest LDL cholesterol tertile were as follows:
- 0.80 (0.65‐0.98) for middle tertile, and
- 0.72 (0.54‐0.95) for highest.
- Results for LDL and total cholesterol were not significant.
- Results for high-density lipoprotein cholesterol were not significant for men or women.
- Population-based cohort study; n=261,638, age 40-79 years, not receiving statins.
- Repeated measures were taken during 1999-2012; mean follow-up, 7.9±3.6 years.
- Funding: Michael J. Fox Foundation; National Parkinson Foundation; European Union 7th Framework Program; Israel Science Foundation; Teva National Network of Excellence in Neuroscience; Biogen; Lysosomal Therapeutic, Inc.; AbbVie; Bioeye.
- Not including participants receiving statins means excluding those with highest cholesterol levels.
- A lot of demographic information was not available.