High cholesterol is linked to reduced Parkinson’s risk in men

  • Rozani V & al.
  • Mov Disord
  • 25 Aug 2018

  • curated by Emily Willingham, PhD
  • Clinical Essentials
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Takeaway

  • High levels of low-density lipoprotein (LDL) cholesterol and total cholesterol are linked to reduced risk for Parkinson’s disease (PD) in men.

Why this matters

  • The authors say that a role for cholesterol in neurodegeneration is unclear.
  • Other studies examining this potential link have included confounders, and the direction of the association is not clear.

Key results

  • Pooled HRs (95% CI) for PD risk in men vs lowest total cholesterol tertile were as follows:
    • 0.82 (0.661.01) for middle tertile, and
    • 0.71 (0.550.93) for highest.
  • Pooled HRs (95% CI) for PD risk vs lowest LDL cholesterol tertile were as follows:
    • 0.80 (0.650.98) for middle tertile, and
    • 0.72 (0.540.95) for highest.
  • Results for LDL and total cholesterol were not significant.
  • Results for high-density lipoprotein cholesterol were not significant for men or women.

Study design

  • Population-based cohort study; n=261,638, age 40-79 years, not receiving statins.
  • Repeated measures were taken during 1999-2012; mean follow-up, 7.9±3.6 years.
  • Funding: Michael J. Fox Foundation; National Parkinson Foundation; European Union 7th Framework Program; Israel Science Foundation; Teva National Network of Excellence in Neuroscience; Biogen; Lysosomal Therapeutic, Inc.; AbbVie; Bioeye.

Limitations

  • Not including participants receiving statins means excluding those with highest cholesterol levels.
  • A lot of demographic information was not available.

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