- Among internal medicine unit inpatients, statin treatment overall is associated with reduced hypoglycemia.
- For those with low admission serum albumin, however, high-intensity statins are associated with increased hypoglycemia (
Why this matters
- Inpatient hypoglycemia is linked to decreased 1-year survival.
- Retrospective study of 31,094 patients discharged from internal medicine wards, 2010-2013.
- Funding: None.
- Compared with 6.7% of patients overall and 6.5% of all statin-treated patients experiencing ≥1 documented inpatient hypoglycemia event, overall rates among those with diabetes and those with low (
- Hypoglycemia rates with:
- Low-intensity statins: 5.0%;
- Moderate-intensity statins: 6.7%; and
- High-intensity statins: 6.4%.
- Among patients with low albumin, high- vs low-intensity statins were associated with higher hypoglycemia incidence:
- Significantly so without diabetes: 9.3% vs 4.8% (P<.05>
- Trending to significance with diabetes: 25.2% vs 17.7% (P=.087).
- No such relationship was seen with albumin >3.5 g/dL.
- Low-intensity statins: 2.0%;
- Moderate-intensity statins: 2.1%;
- High-intensity statins: 2.4%; and
- No statins: 3.4%.