High prevalence of obstructive sleep apnoea in women with polycystic ovary syndrome

  • Kahal H & al.
  • Sleep Breath
  • 20 May 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • This meta-analysis suggests that the prevalence of obstructive sleep apnoea (OSA) is higher in women with polycystic ovary syndrome (PCOS) and obesity.

Why this matters

  • Findings suggest that physicians should have a high index of suspicion of OSA in women with PCOS.

Study design

  • 17 studies involving 648 participants met the eligibility criteria after a search on MEDLINE, Embase, CINAHL, PsycINFO, Scopus, Web of Science, and other electronic databases.
  • Funding: None disclosed.

Key results

  • The pooled prevalence of OSA was 35.0% (95% CI, 22.2-48.9%; I2, 92%) in women with PCOS.
  • Women with PCOS were 4 times more likely to develop OSA vs control participants (8 studies [n=957]; OR, 3.83, 95% CI, 1.43-10.24).
  • The prevalence of OSA was 38% higher in women with obesity vs non-obese women with PCOS (2 studies; prevalence difference, +37.9%, 95% CI, 15.0-60.9%).

Limitations

  • Heterogeneity among included studies.
  • Risk of selection bias.