High sensitivity C‐reactive protein may predict angiographic severity of coronary artery disease

  • Tajfard M & al.
  • J Cell Physiol
  • 12 Dec 2018

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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  • Elevated serum high sensitivity C‐reactive protein (hs‐CRP) levels are significantly associated with severity of coronary artery disease (CAD) on coronary angiography, suggesting its value as a biomarker for predicting CAD.

Why this matters

  • Findings suggest serum hs‐CRP may be a simple, reproducible and reliable biomarker to predict severity of CAD risk and help physicians in prognosis and diagnosis of cardiovascular disease.

Study design

  • This case-control study included 2346 participants (with CAD and subjected to angiography, 1187; control group, 1159) from September 2011 to May 2013.
  • Glycaemic profile, lipid profile, hs‐CRP levels and severity of CAD were compared between the two groups.
  • Funding: Mashhad University of Medical Sciences and University Putra Malaysia.

Key results

  • Serum hs‐CRP levels were higher in those with severe coronary disease, who had stenosis ≥50% in at least one coronary artery (P<.001 for all and showed significant association with severity of coronary artery disease vs control group.>
  • After adjustment for conventional risk factors, smoking habits, fasting blood glucose, total cholesterol, high‐density lipoprotein, hs‐CRP, blood pressure, anxiety, dietary intake of vitamin E and cholesterol were associated with severity of CAD (P<.05>
  • The area under the receiver operating characteristic curve for serum hs‐CRP was 0.869 (P<.001 and optimal values for the cut point hs to predict severity of cad were mg specificity>


  • Overestimation or underestimation of mean scores.
  • Findings were not generalised to all patients with cardiovascular disease.

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