- Elevated serum high sensitivity C‐reactive protein (hs‐CRP) levels are significantly associated with severity of coronary artery disease (CAD) on coronary angiography, suggesting its value as a biomarker for predicting CAD.
Why this matters
- Findings suggest serum hs‐CRP may be a simple, reproducible and reliable biomarker to predict severity of CAD risk and help physicians in prognosis and diagnosis of cardiovascular disease.
- This case-control study included 2346 participants (with CAD and subjected to angiography, 1187; control group, 1159) from September 2011 to May 2013.
- Glycaemic profile, lipid profile, hs‐CRP levels and severity of CAD were compared between the two groups.
- Funding: Mashhad University of Medical Sciences and University Putra Malaysia.
- Serum hs‐CRP levels were higher in those with severe coronary disease, who had stenosis ≥50% in at least one coronary artery (P<.001 for all and showed significant association with severity of coronary artery disease vs control group.>
- After adjustment for conventional risk factors, smoking habits, fasting blood glucose, total cholesterol, high‐density lipoprotein, hs‐CRP, blood pressure, anxiety, dietary intake of vitamin E and cholesterol were associated with severity of CAD (P<.05>
- The area under the receiver operating characteristic curve for serum hs‐CRP was 0.869 (P<.001 and optimal values for the cut point hs to predict severity of cad were mg specificity>
- Overestimation or underestimation of mean scores.
- Findings were not generalised to all patients with cardiovascular disease.