- High statin use was associated with a decreased risk of lung cancer in patients with hypercholesterolemia.
- Benefit was noted regardless of smoking history but was greatest among current smokers.
Why this matters
- Studies on the benefit of statins in cancer prevention have produced conflicting results.
- 16,588 male patients with hypercholesterolemia from the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea who were high statin users (n=4050), low statin users (n=4050), or nonusers (n=8488).
- Funding: Yonsei University College of Medicine.
- 48.8% of overall cohort used statins.
- 2.2% of overall cohort diagnosed with lung cancer.
- Compared with nonusers, high statin use was independently associated with a decreased risk of cancer compared with low statin use (aHRs, 0.64; 95% CI, 0.47-0.85 and 1.03; 95% CI, 0.80-1.33, respectively) after adjustment for confounders.
- Compared with nonusers, high statin use was also associated with reduced lung cancer risk among a smoking subgroup after adjusting for confounders (aHR, 0.83; 95% CI, 0.52-1.31 for nonsmokers; aHR, 0.59; 95% CI, 0.27-1.29 for ex-smokers; and aHR, 0.50; 95% CI, 0.32-0.79 for current smokers).
- Retrospective study with all-male, all-Korean cohort.