- Elevated levels of thyroid-stimulating hormone (TSH) are associated with increased miscarriage risk during early pregnancy, according to a prospective case-control study.
Why this matters
- The link between subclinical hypothyroidism, a common condition in pregnant women, and risk for miscarriage is controversial.
- Higher TSH levels were associated with spontaneous miscarriage risk (OR, 1.21; P<.001 in logistic regression analysis.>
- TSH levels of 2.5 to
- OR, 1.47 (95% CI, 1.15-1.89) and OR, 2.52 (95% CI, 1.41-4.48), respectively, in thyroid peroxidase antibody-negative subjects.
- 421 women who experienced miscarriage before 20 weeks and 1684 control individuals were analyzed for associations with thyroid hormone levels.
- Funding: National Science and Technology Support Program, Chinese National Natural Science Foundation, Health and Medicine Research Foundation in Shenyang City.
- Study lacks data on potential confounders such as environmental toxins, irregular menstruation, family history of miscarriage, and antiphospholipid antibodies.
- Chromosomal anomalies and human chorionic gonadotropin values not evaluated.