High TSH levels tied to miscarriage risk in early pregnancy

  • Li J & al.
  • Endocr Connect
  • 1 Sep 2019

  • International Clinical Digest
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Takeaway

  • Elevated levels of thyroid-stimulating hormone (TSH) are associated with increased miscarriage risk during early pregnancy, according to a prospective case-control study.

Why this matters

  • The link between subclinical hypothyroidism, a common condition in pregnant women, and risk for miscarriage is controversial.

Key results

  • Higher TSH levels were associated with spontaneous miscarriage risk (OR, 1.21; P<.001 in logistic regression analysis.>
  • TSH levels of 2.5­ to
  • OR, 1.47 (95% CI, 1.15-1.89) and OR, 2.52 (95% CI, 1.41-4.48), respectively, in thyroid peroxidase antibody-negative subjects.

Study design

  • 421 women who experienced miscarriage before 20 weeks and 1684 control individuals were analyzed for associations with thyroid hormone levels.
  • Funding: National Science and Technology Support Program, Chinese National Natural Science Foundation, Health and Medicine Research Foundation in Shenyang City.

Limitations

  • Study lacks data on potential confounders such as environmental toxins, irregular menstruation, family history of miscarriage, and antiphospholipid antibodies.
  • Chromosomal anomalies and human chorionic gonadotropin values not evaluated.

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