- High serum vitamin D (25-hydroxyvitamin D [25(OH)D]) is associated with improved lung function biomarkers by spirometry but not with lower prevalence of asthma, emphysema, and chronic bronchitis.
- Results are from an analysis of a nationally representative sample of almost 12,000 US adults.
Why this matters
- Randomized controlled trials of vitamin D supplementation are needed, especially of smokers.
- 11,983 US adults in the National Health and Nutrition Examination Surveys, 2007-2012.
- Primary outcome: results of lung function biomarkers FVC and FEV1.
- Prevalence of asthma, emphysema, and chronic bronchitis determined by patient self-report.
- Funding: None.
- Serum 25(OH)D levels were directly associated with FVC and FEV1 (P for trend<.001>
- Highest quartile 25(OH)D was associated with higher FVC and FEV1 vs lowest quartile (each P<.001 on multivariate analysis>
- Results were similar when stratified by smoking status (nonsmoker vs smoker) and sex (male vs female).
- Self-report of lung disease.
- Cross-sectional, observational design.