- Men who engage in high levels of physical activity tend to have elevated coronary artery calcification (CAC) scores, but they do not have increased mortality at a decade of follow-up.
Why this matters
- Some evidence points to higher CAC scores with physical activity exceeding 1 hour a day.
- Commentary: “very high doses of running and exercise can be performed safely and heavily, even with hearts of stone.”
- Men who had high physical activity (≥3000 metabolic equivalent of task [MET] minutes/week) and CAC
- HR, 0.52 (95% CI, 0.29-0.91).
- CAC of ≥100 and ≥3000 MET minutes/week had no increased mortality risk vs
- HR, 0.77 (95% CI, 0.52-1.15).
- In men with lowest activity, CAC of ≥100 had doubled cardiovascular mortality risk:
- HR, 1.93 (95% CI, 1.34-2.78).
- Prospective, observational study of 21,758 men (age, 51.7 [standard deviation, 8.4] years).
- Funding: National Space Biomedical Research Institute.
- Homogeneous population.