- This meta-analysis suggests that higher levels of total daily sitting time are associated with an increased risk for cardiovascular disease (CVD) and diabetes, independent of physical activity.
Why this matters
- Findings support a focus on reducing total daily sitting time in public health guidelines.
- 9 studies (n=448,285) that examined the association between total daily sitting time and CVD or diabetes outcomes were identified after a search across electronic databases.
- Funding: None.
- Higher total daily sitting time was associated with a significantly increased risk for CVD (HR, 1.29; 95% CI, 1.27-1.30) and diabetes (HR, 1.13; 95% CI, 1.04-1.22; I2, 53%; P<.001 for both when not adjusted physical activity.>
- After adjustment for physical activity, the risk for diabetes (HR, 1.11; 95% CI, 1.01-1.19) and CVD (HR, 1.14; 95% CI, 1.04-1.23; P<.001 for both was significantly increased with a higher total daily sitting time.>
- Use of self-report questionnaires to measure exposure.
- Physical activity was self-reported, and its outcomes were not consistent across studies.