HIV exposure tied to impaired infant growth

  • Jumare J & al.
  • Pediatr Infect Dis J
  • 9 Nov 2018

  • curated by Emily Willingham, PhD
  • Medical News
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Takeaway

  • Nigerian children exposed to HIV but uninfected (HEU) show impaired growth in their first 18 months compared with unexposed peers (HUU).
  • Option B antiretroviral treatment (ART) is high in this population.

Why this matters

  • Authors say this report is the first to track growth in HEU vs HUU children with appropriately “robust” methodology.

Key results

  • Apgars, preterm birth rates were not different between groups.
  • Stunting rates at birth:
    • 32% among HEU vs
    • 17.9% among HUU children (P=.006).
  • At age 18 months, stunting rates were
    • 44.3% HEU and
    • 30.9% HUU (P=.045).
  • Underweight rates at birth:
    • 2.9% among HEU children vs
    • 0% among HUU.
  • At 18 months, underweight rates were
    • 15.8% for HEU vs
    • 6.2% for HUU children (P=.032).
  • aOR, stunting in HEU vs HUU children: 2.4 (95% CI, 1.4-4.1; P=.001).
  • aOR, underweight in HEU vs HUU children: 1.6 (95% CI, 1.1-2.2; P=.009).
  • Breastfeeding rates similar to age 6 months.

Study design

  • 415 infants (307 HEU; 108 HUU), Plateau State Specialist Hospital, Jos, Nigeria. 
  • Followed to age 18 months.
  • Age-, sex-standardized z-scores using WHO standards.
  • Funding: Global Health Research Initiative.

Limitations

  • Some loss to follow-up, including for infant and maternal deaths; nonsignificant between groups.
  • Excluded “implausible” values (

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