- Nigerian children exposed to HIV but uninfected (HEU) show impaired growth in their first 18 months compared with unexposed peers (HUU).
- Option B antiretroviral treatment (ART) is high in this population.
Why this matters
- Authors say this report is the first to track growth in HEU vs HUU children with appropriately “robust” methodology.
- Apgars, preterm birth rates were not different between groups.
- Stunting rates at birth:
- 32% among HEU vs
- 17.9% among HUU children (P=.006).
- At age 18 months, stunting rates were
- 44.3% HEU and
- 30.9% HUU (P=.045).
- Underweight rates at birth:
- 2.9% among HEU children vs
- 0% among HUU.
- At 18 months, underweight rates were
- 15.8% for HEU vs
- 6.2% for HUU children (P=.032).
- aOR, stunting in HEU vs HUU children: 2.4 (95% CI, 1.4-4.1; P=.001).
- aOR, underweight in HEU vs HUU children: 1.6 (95% CI, 1.1-2.2; P=.009).
- Breastfeeding rates similar to age 6 months.
- 415 infants (307 HEU; 108 HUU), Plateau State Specialist Hospital, Jos, Nigeria.
- Followed to age 18 months.
- Age-, sex-standardized z-scores using WHO standards.
- Funding: Global Health Research Initiative.
- Some loss to follow-up, including for infant and maternal deaths; nonsignificant between groups.
- Excluded “implausible” values (