HIV with high CD4 count: early ART reduces risk for severe bacterial infections
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Immediate antiretroviral therapy (ART) reduces risk for a broad spectrum of severe bacterial infections in HIV-infected patients, and appears to be mediated partly by increases in CD4 cell count, but not neutrophils.
Why this matters
Effect of early ART on bacterial infections is important because these events are common in HIV-infected patients.
After median follow-up of 2.8 y, 120 of 4685 HIV-positive patients had severe bacterial infections (immediate-initiation group n=34, deferred-initiation group n=86).
Immediate vs deferred ART was associated with reduced risk for severe bacterial infection (HR, 0.39; P<.0001).
Average neutrophil and CD4 cell counts were 321.4 cells per μL and 194.2 cells per μL higher, respectively, in immediate- vs deferred-initiation groups (P<.0001).