HLA genotyping unhelpful as celiac screen in children with type 1 diabetes
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Counter to recent European Society for Paediatric Gastroenterology, Hepatology, and Nutrition guidelines, HLA genotyping in patients with type 1 diabetes (T1D) is not useful to screen for celiac disease (CD).
Instead, celiac-specific antibody screens should be performed regularly in patients with T1D.
Why this matters
CD and T1D are associated.
HLA genotyping via PCR performed on 121 pediatric patients with T1D.
Funding: None listed.
Positive celiac-specific HLA DQ genotypes found in 92% of patients.
In 17% (20 patients) of the celiac-specific HLA-positive individuals, a tissue-transglutaminase IgA antibody (tTGA) was detected, but 1 patient tested mildly positive for tTGA although HLA DQ2 and DQ8 were negative.